Effect of polyherbal mixtures on the treatment of diabetes. Comparative study on morphoanatomy of leaf, stem and root. Formulation development and evaluation of antidiabetic. Pdf effect of chronic administration of boerhavia diffusa linn. The alcoholic extracts of tribulus terrrestris fruits and boerhaavia diffusa roots as shown significant activity on comparison to the synthetic drug spironolactone, poly herbal formulation cystone and to the other extracts of the drug, the furosemide was found to non active on formed crystals. All the formulations showed predominant activity against selected species. In order to ensure correct botanical standardization to remove the controversy, a detailed pharmacognostic study on whole plant of solanum nigrum linn has been. Asian journal of biochemical and pharmaceutical research 2015 coden issn. Boerhaavia diffusa belonging to family nyctaginaceae has a wide distribution, occurring on major part of the globe. Boerhaavia diffusa is a tropical crawling root plant, with bioactive compounds in both. Pdf boerhaavia diffusa is one of the renowned medicinal plants used to treat large number of human ailments as mentioned in ayurveda, charaka samhita. Antidiabetic activity of a polyherbal formulation drfay. Evaluation of antidiabetic activity of a herbal formulation. Habit erectdiffuse branched herbs glabrous, pubescent, diffuse.
Nyctaginaceae was obtained as a gift sample from aimil pharmaceutical india limited, new delhi. Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice. Streptozotocin induced type 2 diabetic model is a widely used and validated animal model as the induced diabetic condition has close. Herbal formulation was prepared with the mixture of. Antidiabetic activity of a polyherbal formulation in. Polyherbal formulations based on indian medicinal plants as. Rats were randomly divided into 6 groups containing 8 rat in each group. The boerhaavia diffusa plant contains a large number of such compounds as flavonoids, alkaloids, steroids. Polyherbal formulations based on indian medicinal plants. With this background, the present research work was undertaken to standardize and evaluate antidiabetic and antihyperlipidemic activities of a polyherbal formulation, ojamin, using streptozotocin stzinduced diabetic model in rats. Antidiabetic activity of polyherbal formulation 601 into 5 groups of 6 rats each.
Anti arthritic evaluation of ddifferent extracts of boerhaavia diffusa linn. An inhibition of nk cell activity has been noted with an ethanolic extract of the herb, yet further testing failed to find any influence from eupalitin or its glycoside. Group iii and iv were treated orally with drfay5001 300 and 600 mgkg, respectively. Chemotherapeutic potential of boerhaavia diffusa linn. In different areas of the world, boerhaavia diffusa has also been used for pain relief, anti inflammation, and treating indigestion. Phytochemical, therapeutic, and ethnopharmacological. Rjpt pharmacological activities of boerhaavia diffusa. Formulation and evaluation of antiseptic polyherbal ointment. Research article polyherbal formulations for anti diabetic therapy h. It is being sold in the market under the common name makoy. Unlike a single chemical entity that forms the basis of conventional medicine, traditional ayurvedic medicine views the polyherbal preparations as they induce combined therapeutic activity. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key enzymes in experimental diabetes. Comparative study on morphoanatomy of leaf, stem and root of boerhaavia diusa l. Phytochemical and biological importance of boerhavia.
Review plant kingdom nutraceuticals for diabetesarticle. Nyctaginaceae and its adulterant plants 435 table i boerhaavia diffusa are differentiated on the basis of following morphological characters boerhaavia diffusa l. Furthermore, the study investigated effect of simultaneous administration of oj and metformin in diabetic rats. Boerhavia diffusa an overview sciencedirect topics. P,india,2 departmentbarkatullah university, 3 drug technology, faculty of medical technology derna, libya received. Boerhavia diffusa herb uses, benefits, cures, side effects. Many herbs and spices are known to be antihyperglycemic. Use as a single drug and use of more than one drugs, in which the latter is known as phf. Stress was induced by subjecting animals to cold restraint. The adaptogenic activity of boerhavia diffusa extract is due to flavonoids. Several researchers have confirmed biological, pharmacological and clinical activities of the plant and its phyto constituents. Liv52 has been in the market for half a century and is widely marketed in india for the therapy of chronic liver diseases.
Design and development of a stable polyherbal formulation. The mechanism of its analgesic effect was not known. The whole plant or its specific parts leaves, stem, and roots are known to have medicinal properties and have a long history of. Further, polyherbal formulations were evaluated for its anti bacterial activity against staphylococcus aureus, pseudomonas sp. There was significant reduction in total cholesterol, ldl cholesterol, vldl cholesterol and improvement in hdl cholesterol in diabetic rats. Historically, boerhaavia diffusa has been used for its anti diabetic and diuretic properties. Detail study on boerhaavia diffusa plant for its medicinal. Cardiovascular agents, anti obese agents, anti diabetic agents, anti cancer agents, immune boosters, substances that manage chronic inflammatory disorders and formulations to cure degenerative diseases. Group i and ii served as normal and diabetic control respectively and received vehicle 1 mlkg, po.
Polyherbal, formulation, antidiabetic activity, medicinal plants, type 2 diabetes, ayurvedic. Results of short term stability study were also found to be satisfactory and were comparable to initial formulation. Pdf detail study on boerhaavia diffusa plant for its. Numerous plants and polyherbal formulations are used for the treatment of renal diseases. In the present study the antihyperglycemic, hypolipidemic and antioxidant properties of newlinethe specially formulate polyherbal formulation in streptozotocin induced diabetic rats newlinewas determined. List of various diseases cured by boerhavia diffusa. The root and aerial parts of boerhaavia diffusa linn. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. Hydroethanolic extract 80% of boerhaavia diffusa hebd and a polyherbal formulation punarnava mandur phf09 containing boerhaavia diffusa were compared for their antistress activity using cold restraint stress model. Review on nephroprotective activity study by different plant extract paoulomi chatterjee 1. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key. Request pdf antidiabetic activity of boerhaavia diffusa l effect on hepatic key.
The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. Asian journal of biochemical and pharmaceutical research. The outcomes of lipid profiles in control and experimental rats are exhibited in table 4. The diabetic animals were randomly divided into eight groups with 8 rats in each group and treated as follows for 14 days continuously orally. Punarnava mandur contains boerhaavia diffusa, mandur bhasm, varun, bharangi. Asian journal of biochemical and pharmaceutical research evaluation of hepatoprotective efficacy of polyherbal formulation amlycure ds on anti tubercular drug induced hepatotoxicity anil kumar. Antidiabetic, antihyperlipidemic activities and herbdrug interaction of a polyherbal formulation in streptozotocin induced diabetic rats. Antidiabetic activity of a polyherbal formulation diab et. Formulation and anti diabetic activity studies of herbomineral formulation for treatment of diabetes. The extract antidiabetic activity was comparable to that of the antidiabetic drug glibenclamide. The present study was aimed to evaluate the anti diabetic activity potential of boerhaavia diffusa roots against streptozotocin induced experimental rats.
Hence, the prepared polyherbal formulation f9 can be used as a stable, patient compliant and cost effective solid dosage form. Evaluation of anti diabetic activity of the polyherbal formulation 16. Hyperlipidemia is an associated complication of diabetes mellitus. The efficacy of prepared mixtures has been tested on streptozotocin stz induced diabetic. Medicinal plants with potential antiarthritic activity. The animals of diabetic control showed significant increase in serum tgl, total cholesterol and ldl while increase in hdl when compared with normal animals. Kaur, anti convulsant activity of boerhaavia diffusa. Antidiabetic activity of polyherbal formulation on. Asian journal of pharmaceutical and clinical research. The aim of the present study was to determine the anti diabetic activity of a polyherbal formulation in streptozotocin induced type 2 diabetic rats.
Kakamachi solanum nigrum linn belongs to family solanaceae and is being used in ayurveda in skin diseases and diabetes. Uses, benefits, cures, side effects, nutrients in boerhavia diffusa. Vishnu p choudhari maeers maharashtra institute of pharmacy, mit campus, paud road, kothrud, pune, maharashtra 411038, india. Comparative screening of polyherbal preparations for anti diabetic and antioxidant activity in rats. Names of boerhavia diffusa in various languages of the world are also given. The blood glucose lowering activity of the polyherbal preparation 1and 2 was studied in normal rats and alloxaninduced diabetic rats after oral administration at doses of 1. Blood samples were collected from the tail vein method on 1,7. The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of boerhavia diffusa leaves in alloxan diabetic rats. Some of the promising effects of this plant include diuretic, hepatoprotective, anti inflammatory, anti fibrinolytic, anti cancer, anti diabetic, immunomodulatory, immunosuppressive, anti. The polyherbal formulation nrkft and authenticated whole plant of boerhaavia diffusa family. Diabetes mellitus, polyherbal, sodium starch glycolate, crosspovidone. This key traditional therapeutic herbal strategy exploits the combining of several medicinal herbs to achieve extra therapeutic effectiveness, usually known as polypharmacy or polyherbalism.
An overview on anti diabetic activity of siddha medicinal plants. The hydroalcoholic extracts of eugenia jambolana, gymnema sylvestre, momordica charantia and andrographis paniculata and sodhana processed extract of myristica fragrans were prepared. Rjpt antidiabetic potential of a traditional polyherbal. Elucidation of m echanism of anti athritic actio n of arthosansara. How boerhavia diffusa is effective for various diseases is listed in repertory format. Pharmacological properties of boerhavia diffusa international. Boerhaavia diffusa from traditional use to scientific. The extraordinary antioxidant, hepatoprotective, antibiotic, antidiabetic and anticarcinogenic properties of b. This paper explains the evidencebased information regarding the pharmacological activity of this plant. The study proved that the active anti nociceptive principle of b. Antidiabetic, antihyperlipidemic activities and herbdrug.